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Brand name: Phesgo

Chemical name: Pertuzumab, trastuzumab, and hyaluronidase-zzxf

Class: Phesgo is a combination of Perjeta (chemical name: pertuzumab), Herceptin (chemical name: trastuzumab), and hyaluronidase-zzxf. Herceptin and Perjeta are HER2 (human epidermal receptor 2) inhibitor-targeted therapies. Herzuma, Kanjinti, Margenza, Nerlynx, Ogivri, Ontruzant, Trazimera, and Tykerb are other HER2 inhibitors. Hyaluronidase-zzxf is an enzyme that helps the body absorb Herceptin and Perjeta.

How it works: HER2 inhibitors work against HER2-positive breast cancers by blocking the ability of the cancer cells to grow.

Uses: Phesgo can be used in combination with chemotherapy:

  • before surgery for early-stage or inflammatory HER2-positive breast cancer
  • after surgery for early-stage HER2-positive breast cancer with a high risk of recurrence

Phesgo also can be used in combination with Taxotere (chemical name: docetaxel) to treat HER2-positive metastatic breast cancer that has not been treated with anti-HER2 therapy or chemotherapy.

How it’s given: Phesgo is given as an injection under the skin in the thigh. When a medicine is injected under the skin, it’s called a subcutaneous injection.

Side effects:

Rare but serious side effects:

Read more about Phesgo.

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  1. Phesgo (pertuzumab, trastuzumab, and hyaluronidase-zzxf) prescribing information. 2020. Available at: (PDF)

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