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Brand name: Piqray

Chemical name: Alpelisib

Class: PI3K inhibitor

How it works: The PI3K pathway helps all cells — both healthy and cancer cells — get the energy they need. When this pathway is overactivated because of a mutation in the PIK3CA gene, it can allow cancer cells to survive and grow. PI3K inhibitors block this pathway, with the goal of killing cancer cells.

Uses: Piqray is used in combination with Faslodex (chemical name: fulvestrant) to treat metastatic and advanced-stage, hormone-receptor-positive, HER2-negative breast cancer with a PIK3CA mutation that has grown after hormonal therapy treatment in postmenopausal women and men.

How it’s given: Piqray is a pill taken by mouth.

Side effects:

Read more about Piqray.

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  1. Piqray (alpelisib) prescribing information. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey. 2019. Available at: (PDF)

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